|
KMID : 1234920220220010001
|
|
Journal of Korean Oriental Association for Study of Obesity
2022 Volume.22 No. 1 p.1 ~ p.10
|
|
|
Hesperidin and Hesperetin Protect against Oxidative Stress on Hepatic Toxicity in Rats
|
|
Kim Ji-Hyun
Li Li
Kim Mi-Suk
Cho Eun-Ju
Kim Hyun-Young
Choi Jine-Shang
|
|
|
Abstract
|
|
|
Objectives: To investigate the protective effect of hesperidin and hesperetin against oxidative stress in 2,2'-azobis (2-aminopropane) dihydrochloride (AAPH)-induced liver toxicity in rats.
Methods: Hesperidin or hesperetin (200 mg/kg/day, respectively) was orally administered for 7 days once daily in rats. Subsequently, AAPH (50 mg/kg/day) was administered intraperitoneally. Lipid peroxidation, nitric oxide production, catalase activity, and protein expressions of nuclear factor-kappa B (NF-κB) and inducible nitric oxide synthase (iNOS) in the liver tissues were measured.
Results: Administration of hesperidin and hesperetin significantly decreased serum aspartate transaminase and alanine transaminase levels in AAPH-induced oxidative stress liver tissues compared with control group. Lipid peroxidation and nitric oxide (NO) production were also significantly reduced by hesperidin and hesperetin in AAPH-induced oxidative stress liver tissues. In particular, lipid peroxidation levels of hesperetin-administered group significantly decreased to 5.02 nmole/mg protein in oxidative stress rats. Hesperidin and hesperetin significantly increased antioxidant activity, such as that of catalase.
Furthermore, administration of hesperidin and hesperetin substantially down-regulated the expression of NF-κB and iNOS in liver tissues. Administration of hesperidin reduced NO levels and iNOS expression more than in the hesperetin-administered group.
Conclusions: Administration of hesperidin and hesperetin led to a reduction in AAPH-induced liver toxicity by regulating oxidative stress.
|
|
|
KEYWORD
|
|
|
Oxidative stress, Hesperidin, Hesperetin, Catalase, Nitric oxide
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|